Research
The main focus of Keith Barton’s research has been the surgical management of glaucoma, although he has also been involved in other areas of glaucoma research. The studies in which he is involved or have been involved are grouped below according to area of focus.
Aqueous Shunt Trials
- 2002 – 2012 – Tube versus trabeculectomy (TVT) Study
United States-based multi-centre randomised surgical trial. 212 patients were randomized in this 17 centre investigator-initiated trial which published 5 years of follow-up in 2012. Steering committee member, principal investigator at Moorfields Eye Hospital and only non-US investigator. - 2006 – 2015 – Ahmed Baerveldt Comparison (ABC) Study
US-based international multi-centre randomised surgical trial. 276 patients were randomised in this 16 centre investigator-initiated trial which published 5 years of follow-up in 2015. Co-chairman of study and principal investigator at Moorfields Eye Hospital. - 2008 – present – Primary Tube versus Trabeculectomy (PTVT) Study
US-based international multi-centre randomised surgical trial. Recruitment of 242 patients was completed in 2015. Treatment outcomes and surgical complications after one year of follow-up were presented at the American Academy Annual meeting in Chicago 2016. Steering committee member and principal investigator at Moorfields Eye Hospital. - 2008 – present – Primary Tube versus Trabeculectomy (PTVT) Study
Corneal Endothelial Ancillary Study. Chief Investigator. - 2010 – 2020 – Prospective study of risk factors for corneal endothelial failure after aqueous shunt implantation
This study of consecutive patients implanted with aqueous shunts under Keith Barton’s care with planned 5-year follow-up identified tube entry site position as an important risk factor for corneal endothelial cell loss after aqueous shunt implantation and was presented at the American Glaucoma Society in Washington DC in February 2020.
Trabeculectomy Trials
- 2014 – 2020 – Treatment of Advanced Glaucoma Study (TAGS)
Investigator-initiated, NIHR-HTA funded UK based multi-centre randomised controlled trial comparing primary medical treatment with primary trabeculectomy in 440 patients with newly diagnosed advanced glaucoma.
Co-investigator and member of Trial Management Group.
Glaucoma Laser Therapy Trials
- 2012 – present – Health-Related Quality of Life in two treatment pathways for open angle glaucoma and ocular hypertension: A randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy (Light Trial)
Investigator-initiated NIHR-HTA funded multi-centre randomised clinical trial in which 718 patients were recruited by 2014 with planned 3 year follow-up.
Co-investigator and member of trial management group. - 2007 – 2020 – Zhongsham Angle-Closure Prevention (ZAP) Trial
Investigator-initiated randomised, controlled trial of Laser Iridotomy for prevention of angle-closure glaucoma in southern China and subsequently published in The Lancet.
Member of safety and data monitoring committee.